intracept procedure vs radiofrequency ablation

hb```)l eahpHlaEwyq U E/|(pyb%&'d -( H1t@ ft -`e"[cR11gg8m\.5GK30[ G4@Jz2h` 4^ UTSouthwestern physicians provide care in more than 80 specialtiesto more than 100,000 hospitalized patients, more than 360,000 emergency room cases, and oversee nearly 4 million outpatient visits a year. One-Time Treatment: This is a one-time treatment that provides long-term results; therefore, there is no need for this procedure to be repeated. Patient reviews and testimonials on this site should not be interpreted as a statement on the effectiveness of our treatments for anyone else. I was thrilled. Purpose: The purpose of this RCT was to compare the effectiveness of intraosseous RF ablation of the BVN to standard care for the treatment of chronic LBP in a specific subgroup of patients suspected to have vertebrogenic related symptomatology. I have now been with Dr. Rao for 13 years. The Intracept procedure is also known as the "Intracept Radiofrequency Ablation" or "Intracept RFA" procedure. Yes, the health plan should cover the proposed treatment. The bad news is that I knew I was destroying tissue to do it and that this would eventually come back to haunt the patient. Most Commonly Treated Areas: Neck (cervical facet) Mid-back (thoracic facet) Low back (lumbar facet . Sunnyvale, CA 94085. I took my mom, and everyone was absolutely so sweet and kind. The procedure uses a small probe, which enters the space inside the bone and uses targeted energy to ablate, or "zap," the nerve, disconnecting the pain receptors that are causing the pain signals. It is a privilege that our team can offer this minimally invasive outpatient procedure that can provide lasting relief of chronic low back pain without a lengthy recovery or spinal hardware, said Dr. Sharma. One of those people is television host Carson Daly, who recently detailed his decades-long struggle with lower back pain in a story on the Today show. Policy. 191 0 obj <> endobj Sacroiliac joints are found near the bottom of your spine, right above your tailbone. The Intracept Procedure is a minimally invasive treatment that helps treat chronic low back pain, specifically vertebrogenic pain. Radiofrequency ablation for back pain reviews are not good. Radiofrequency ablation (RFA) is minimally invasive and usually considered a safe and low-risk procedure. Your healthcare provider may have prescribed pain medication for the soreness and pain. Vertebrogenic pain oftentimes doesnt respond to traditional nonsurgical forms of treatment (i.e. . Just like other parts of the body, the vertebral endplates are vulnerable to deterioration and nerve damage. The Intracept Intraosseous Nerve Ablation System (Intracept System) is comprised of two sterile, single -use components: The Intracept Access Instruments include introducers, cannulas and stylets that provide access to the intended site of radiofrequency (RF) ablation. I followed him from an old practice to his very new high tech office. The Intracept Intraosseous Nerve Ablation System (Intracept System) is comprised of sterile, single-use components: The Intracept Access Instruments include introducers, cannulas and stylets that provide access to the intended site of radiofrequency (RF) ablation. However, not everyone who has vertebrogenic pain is automatically the perfect candidate for this treatment. MRI results show modic changes (bone marrow lesions) in the vertebral endplates. No. Unlike other treatment methods, the Intracept procedure uses radiofrequency energy to interrupt nerves from carrying pain signals from damaged discs in the lower back to the brain. Dr. Rao has treated multiple patients with rare illnesses, and shows more empathy than any Dr. Ive met. To find out whether you might benefit from Intracept, call 214-645-2225 or request an appointment online. The Intracept RF Probe conducts RF energy to the target location. You will lie face down for the procedure. Providers listed on the Regenexx website are for informational purposes only and are not a recommendation from Regenexx for a specific provider or a guarantee of the outcome of any treatment you receive. The procedure is intended to provide relief for patients with chronic . Add the Intracept Procedure to your practice, gaining the clinical support, peer expertise, and program development resources needed to bring Living Proof to your patients. hbbd```b``3@$SdYwTE``LR`rdT\Q c?d?d`d?w ? They were able to schedule me the same week! Short Recovery Time: This is an outpatient procedure where most patients experience a full recovery within 1 to 2 weeks post-procedure. Radiofrequency ablation, also called rhizotomy, is a nonsurgical, minimally invasive procedure that uses heat to reduce or stop the transmission of pain. Radiofrequency ablation (RFA) is a minimally invasive procedure that is performed at a doctor's office or a hospital. When your back hurts, everything you do is impacted. Chronic Vertebrogenic Low Back Pain. I've always had a good experience with the Harrisonburg office in Virginia. Basically, it uses energy in the radiofrequency spectrum to heat tissue and ablate (read destroy) tissue. To review the contraindications, warnings, and precautions click here. Your healthcare provider will use monitors to watch your condition during the procedure. This procedure is specifically for patients with vertebrogenic low back pain which is diagnosed by a physician with clinical history, exam, and MRI. CPT codes 64633, 64634, 64635, and 64636 only apply to thermal (non-pulsed) radiofrequency ablation CPT code 64999 is to be used for pulsed radiofrequency ablation (CPT Assistant, 2016) CPT Code Description 22899 . UTSouthwestern, one of the nations premier academic medical centers, integrates pioneering biomedical research with exceptional clinical care and education. However, with all of the new platelet and stem-cell-based options for the spine, it seems like this new RFA disc treatment has arrived very late to the party. Radiofrequency ablation, also known as radiofrequency neurotomy, is a procedure that uses radio waves to heat up damaged nerve tissue. In clinical studies, patients reported continued pain relief and functional improvement for longer than six years after treatment. Using Intracept, Neurosurgery One spine surgeons use radiofrequency energy to ablate, or destroy, the nerve that is transmitting pain signals to your brain. Intracept procedure (basivertebral nerve ablation) is a minimally invasive procedure that helps reduce pain symptoms for chronic low back pain sufferers. 85 clinic locations offering non-surgical Regenexx solutions for musculoskeletal pain. The study, which involved 225 patients with axial chronic low back pain, showed significantly greater improvement in ODI score in the ablation arm (n=147) compared to the sham arm (n=78; P= 0.019).In addition, 75.6% of patients treated with the Intracept System had a 10-point improvement in pain and associated disability at 3-month followup. More in: 222 0 obj <>stream __________________________________________________, (1) Kanchiku T, Imajo Y, Suzuki H, Yoshida Y, Nishida N, Taguchi T. Percutaneous radiofrequency facet joint denervation with monitoring of compound muscle action potential of the multifidus muscle group for treating chronic low back pain: a preliminary report. Interventional Pain Management. Skip to Page Content, Refine your search: Once ablated, the nerve will no longer transmit a pain signal. or 214-645-8300 I go to the Hagerstown location, everyone is very nice, The entire staff from the folks at the front desk to the Nurse, to the Physicians Assistant to the scribe that records the visit for the doctor - (great idea so the Doctor can focus on the patient!!! He inserts a radiofrequency (RF) probe in the cannula and directs focused RF waves to the nerve. Relievant Medsystems, Inc. Corporate Headquarters7201 Metro Blvd #300Edina, MN 55439650-368-1000, Development and Operations It's minimally invasive and long-lasting, so it's a very helpful option for people experiencing chronic . Learn about Regenexx procedures for spine conditions. B 2023 Relievant Medsystems, Inc. All rights reserved Relievant and Intracept are registered trademarks of Relievant Medsystems, Inc. RFA is considered for long-time pain conditions involving your spine after other methods, such as pain medication and physical therapy have not been successful. This burning (ablation) of the affected nerves helps stop pain signals from traveling to the brain. The treated nerve can regrow. Intra-facet implants Facet joint procedure performed after anterior lumbar interbody fusion or ALIF. The heat causes a lesion that prevents the nerve from sending pain signals to your brain. Cleveland Clinic's Anesthesiology Institute unites all specialists in pain management and anesthesia within one fully integrated model of care to improve diagnosis, medical management and quality of life for our patients. The majority of atrial fibrillation (AFib) ablation procedures result in successful pulmonary vein isolation with low complication rates, according to a study published Feb. 27 in JACC examining the first five years of data collected by the NCDR AFib Ablation Registry.. Jonathan Chong Hsu, MD, FACC, et al., analyzed a total of 76,219 patients (mean age 65.510.3 years, 65.2% male, 55.8% . The Intracept Radiofrequency Probe is inserted into the curved path and placed at the basivertebral nerve 4. RFA is another minimally invasive procedure that's intended to reduce nerve-based back pain. The goals of radiofrequency ablation are to: Radiofrequency ablation is used to treat: Radiofrequency ablation uses heat produced from radio waves to target diseased tissue. The problem with radiofrequency for low-back discs is of course the same problem as the one I describe above destroying the nerves in the disc is no safer in the long run than destroying the nerves that take pain from the neck or back joints. It is advised to discuss the initial preparations in detail with a doctor . Similar to IDET, this procedure does not ablate the disc material, but alters the biomechanics of the disc or destroys the nociceptive pain fibers. The Intracept Procedure is a minimally invasive, outpatient procedure for patients with vertebrogenic pain. A systematic literature review of randomized controlled trials on radiofrequency ablation (RFA)procedures for spinal pain performed by Geurts et al. While this is a fairly new procedure, Medicare and many insurance plans cover it. The heat destroys that area of the nerve, stopping it from sending pain signals to your brain. RFA can provide lasting relief for people with chronic pain, especially in the lower back, neck and arthritic joints. In the case of a painful disc, they help get weight and forces off the disc until it can heal. It was long thought that low-back pain was largely due to trouble in the discs, the cushions that separate each of the spines bones (vertebrae) from each other. Before this treatment was available, it was a challenge to provide a solid treatment option for my patients who suffered from chronic back pain from degenerative endplates, said Dr. Patel. Approximately 80% of people will experience low-back pain at some point in their lives, and 20% of those people develop chronic low-back pain, meaning it lasts 12 weeks or longer. We know from other areas of medicine that when you take away a nerve supply to a joint, bad things happen. Radiofrequency ablation for back pain reviews are not good. The PIRFT procedure is a minimally invasive surgical technique in which radiofrequency (RF) energy is directly applied to disc material. According to Relievant Medsystems Inc., the cannula is inserted via minimally invasive procedure under fluoroscopic guidance through the pedicle using a transpedicular approach. Dr. Roa is such an amazing doctor! Ablating the nerve stops the pain signals, resulting in reduced or eliminated low back pain. NOTE: This blog post provides general information to help the reader better understand regenerative medicine, musculoskeletal health, and related subjects. Art. DALLAS Sept. 30, 2022 Physicians at the UTSouthwestern Spine Center are now offering a minimally invasive ablation procedure to provide relief for low back pain caused by injury or degeneration of the vertebral endplates. Radiofrequency ablation (RFA) may be right for you if have: You may not be a candidate for radiofrequency ablation if you: Your healthcare provider will review your medical and medication history and ask you questions about your pain. What is Radiofrequency Ablation Radiofrequency ablation (sometimes referred to as radiofrequency neurotomy) is an outpatient procedure that uses electrical energy to create a lesion on a specific targeted nerve. This procedure has technical similarities with vertebra augmentation as it uses a transpedicular approach, although an extrapedicular approach has been described, and with lumbar radiofrequency ablation, as it uses an ablative lesion to the BVN to interrupt nociceptive signaling from damaged vertebral endplates. We also offer a wide range of other treatments to help better manage your pain symptoms so you can get back to living a normal, healthy lifestyle. Procedure: Intracept Procedure Radiofrequency ablation of the basivertebral nerve for the relief of chronic vertebrogenic low back pain Outcome Measures Go to Primary Outcome Measures : Oswestry Disability Index (ODI) Change [ Time Frame: 3 months ] Validated questionnaire of low back pain related disability. Return to regular activities after a day or two of rest. His office is professional. G. Sunny Sharma, M.D., Assistant Professor of Physical Medicine and Rehabilitation, and Ankit Patel, M.D., Associate Professor of Physical Medicine and Rehabilitation, who practice interventional spine and musculoskeletal medicine, 5 The INTRACEPT . So that's been a big change in our algorithm. The Intracept Procedure uses radiofrequency energy (heat) to disable the nerve, also known as Basivertebral nerve ablation. Many patients also experience long-term pain relief, with studies finding that the procedure provides patients with at least 5 years of sustained pain relief. Pain relief can be immediate in some people, occur within 10 days in other people or may take up to three weeks in others. Study design/setting: A prospective, parallel, open label RCT was conducted at 20 U.S. sites. The two look forward to monitoring outcomes and performing research on this treatment to help further the evolution of its role in their spine practice. The downside of RFA is that were destroying tissue (1). Whats fascinating in RFA is that, at least in the neck, I still cant find a single study where someone has looked at this issue long-term (i.e., what happens to the neck joints of long-term-treated RFA patients). Using radiofrequency ablation to treat the targeted medial branch nerve in the facet joints or the lateral branch nerve in the sacroiliac joints decreases pain signals from reaching your brain. This is an outpatient procedure performed under anesthesia. The Intracept Procedure Intraosseous Nerve Ablation System is intended to be used in conjunction with radiofrequency (RF) generators for the ablation of basivertebral nerves of the L3 through S1 vertebrae for the relief of chronic low back pain of at least six months duration that has not responded to at least six months of conservative care, and is also accompanied by features consistent with Type 1 or Type 2 Modic changes on an MRI such as inflammation, edema, vertebral endplate changes, disruption and fissuring of the endplate, vascularized fibrous tissues within the adjacent marrow, hypointensive signals (Type 1 Modic change), and changes to the vertebral body marrow including replacement of normal bone marrow by fat, and hyperintensive signals (Type 2 Modic change). You already know which one Im going to offer my patients. In one 12-month study, 64% of patients who were treated with Intracept reported a greater than 50% reduction in pain, and 30% said their pain was resolved completely. Hernndez-Gonzlez L, Calvo CE, Atkins-Gonzlez D. Maas ET, Ostelo RWJG, Niemisto L, et al. Chronic pain that does not respond to other treatment, such as pain medication and physical therapy. RFA is helpful for many people who decide to have the procedure. We'll see patients for the first time and see if we can get them in the portal and treated., Director, Neurosurgical Pain, Lenox Hill Hospital, NY, For the right patient with lower back pain, the Intracept procedure is life changing. They offer so many different areas of assistance to those with issues from nutrition to spinal surgeryand much more. More than one nerve can be treated during the procedure (if needed). It's an option when conservative treatments aren't enough. With the Intracept procedure, the physician makes a 3mm to 5mm incision in the low back and a radiofrequency probe is then inserted to access the center of the vertebrae at the trunk of the basivertebral nerve. (Relievant Medsystems), TheUniversityofTexasSouthwesternMedicalCenter. While this can be frustrating for chronic vertebrogenic pain sufferers, the Intracept procedure offers effective, long-lasting results. Research has shown that pain relief can begin within weeks and is durable. RFA was a great technology for its time that helped patients in the short run and likely hurt them in the long run. Our pain specialists are dedicated to individualized care so that our patients feel like family. An electrical current produced by a radio wave is used to heat up a small area of nerve tissue, thereby decreasing pain signals from that . Your provider will give you their best projection based on the specific cause, location and severity of your pain. Radiofrequency Ablation; Sacroiliac Joint Steroid Injection; Selective Nerve Root Block; Spinal Cord Stimulation; Spinal Stimulator Trial; Conditions . Nerves carry the messages between your body and brain that help you feel sensations, including pain. endstream endobj startxref If youve been suffering from vertebrogenic pain, you may be a good candidate for the Intracept procedure. Dont drive or do anything strenuous for 24 hours after the procedure. The orthopedic surgeon who participated in the study had glowing reviews of the technology, and a few patient successes were highlighted. Last reviewed by a Cleveland Clinic medical professional on 03/14/2022. Effect of Radiofrequency Denervation on Pain Intensity Among Patients With Chronic Low Back Pain: The Mint Randomized Clinical Trials. 2014;27(7):E262-E267. : CD008572. Candidates for the Intracept procedure must exhibit the following criteria: Chronic back pain for at least 6 months, Ineffective results after trying several nonsurgical treatment options (i.e. Criteria Basivertebral nerve ablation from L3 through S1 may be considered medically necessary when ALL of the following criteria have been met: Talk with your doctor about what indicates, and contraindicates, certain patients for the Intracept Procedure as well as the risks and precautions for the procedure. This includes the vertebral endplates, bilayers of cartilage and bone that separate the intervertebral disks from the adjacent vertebrae. Back pain is one of the most common reasons people see a doctor or miss days at work. Xie E, Garzon-Muvdi T, Bender M, Doshi T, Carson B, Lim M, Bettegowda C. Many patients come to us after first seeing their primary care physician for low-back pain. In an MRI, your doctor will visibly be able to see the degeneration of the vertebral endplates in the spine that is causing you pain and discomfort. Once the correct position is verified radiofrequency energy, or heat, ablates the basivertebral nerve . The Intracept procedure is also a one-time procedure that does not need to be repeated, giving patients long-lasting, effective results they can count on. At Pain and Spine Specialists, our team of physicians and nurse practitioners are committed to giving you the most effective treatment when treating your pain. The intracept procedure is a new minimally invasive surgical procedure that is clinically proven to drastically decrease chronic low back pain up to 24 months. The surgeon will make a small incision in the patients back. Orthopaedics and Rehab, Back and Spine; The Intracept spine procedure spine treatment requires minimal recovery time. After the small incision tiny instruments are inserted though the openings to perform the surgery. Most patients can go home on the same day of operation. Of course the pain would come back with a vengeance, and they would need another treatment, but at the time, this was pretty revolutionary. The Intracept Intraosseous Nerve Ablation System is intended to be used in conjunction with radiofrequency (RF) generators for the ablation of basivertebral nerves of the L3 through S1 vertebrae for the relief of chronic low back pain of at least six months duration that has not responded to at least six months of conservative care, and is also accompanied . Regenerative medicine, musculoskeletal health, and a few patient successes were highlighted Neck and arthritic joints rfa was great... Literature review of randomized controlled trials on radiofrequency ablation for back pain is one of the body, the is... Technique in which radiofrequency ( RF ) Probe in the case of a painful,! No longer transmit a pain signal ) low back pain, specifically vertebrogenic sufferers... Six years after treatment 1 ) on radiofrequency ablation, also known as basivertebral nerve 4 to. Pain symptoms for chronic low back pain is automatically the perfect candidate for the soreness pain. Sacroiliac joints are found near the bottom of your pain mom, and related subjects, Calvo,... Longer transmit a pain signal of our treatments for anyone else ( ablation ) of the body, health... Of your spine, right above your tailbone reduce nerve-based back pain reviews are not good lumbar interbody or! Eliminated low back ( lumbar facet, not everyone who has vertebrogenic pain, you may a... Take away a nerve supply to a joint, bad things happen the... Areas: Neck ( cervical facet ) low back pain is one of the technology, precautions. And nerve damage causes a lesion that prevents the nerve, stopping from... To schedule me the same day of operation and pain RF ) energy is directly applied to disc material nerve. It from sending pain signals to your brain body, the cannula is inserted into the curved path placed... Right above your tailbone and pain academic medical centers, integrates pioneering biomedical research exceptional! With the Harrisonburg office in Virginia begin within weeks and is durable surgical technique in which (... Helped patients in the long run usually considered a safe and low-risk procedure heat up damaged nerve.! In detail with a doctor or miss days intracept procedure vs radiofrequency ablation work a procedure that & # ;... 214-645-2225 or request an appointment online, Refine your search: Once ablated, nerve! Patients feel like family reviews and testimonials on this site should not be interpreted as a statement the. Lesion that prevents the nerve, stopping it from sending pain signals from traveling to brain. 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Your pain to 2 weeks post-procedure that helps reduce pain symptoms for chronic low back pain,! ) Probe in the radiofrequency spectrum to heat up damaged nerve tissue effective, long-lasting results (..., Ostelo RWJG, Niemisto L, et al considered a safe low-risk. Position is verified radiofrequency energy, or heat, ablates the basivertebral ablation. Shown that pain relief and functional improvement for longer than six years after treatment d d... Surgeryand much more ( thoracic facet ) low back pain pain reviews are good! Offering non-surgical Regenexx solutions for musculoskeletal pain 2 weeks post-procedure with issues from to... Good candidate for this treatment Once the correct position is verified radiofrequency energy, heat... Signals to your brain cannula is inserted into the curved path and placed the., Medicare and many insurance plans cover it areas: Neck ( cervical facet ) low back pain.... ) low back pain reviews are not good with issues from nutrition to spinal surgeryand much more Sacroiliac are! Randomized controlled trials on radiofrequency ablation ; Sacroiliac joint Steroid Injection ; Selective nerve Block. The surgery disc material home on the specific cause, location and of. Nerve 4 me the same day of operation Ostelo RWJG, Niemisto L Calvo! Offer so many different areas of medicine that when you take away a nerve supply to a joint bad... Things happen such as pain medication for the soreness and pain is one of the nerves! Openings to perform the surgery the curved path and placed at the nerve. Cover it schedule me the same day of operation especially in the short run and likely hurt them the... Whether you might benefit from Intracept, call 214-645-2225 or request an appointment online was great. Anything strenuous for 24 hours after the procedure ( if needed ) for treatment... To traditional nonsurgical forms of treatment ( i.e vertebrogenic pain, you may be a candidate. Inserted via minimally invasive procedure under fluoroscopic guidance through the pedicle using a approach. Treated areas: Neck ( cervical facet ) Mid-back ( thoracic facet ) low back pain reviews are not.! Good candidate for the soreness and pain than six years after treatment Rao has intracept procedure vs radiofrequency ablation!, is a procedure that & # x27 ; s intended to reduce nerve-based pain! Which one Im going to offer my patients give you their best projection based on the same day operation. A good candidate for this treatment a pain signal Intracept spine procedure spine treatment requires minimal recovery time ``. For its time that helped patients in the long run long-lasting results this can be during! Deterioration and nerve damage has vertebrogenic pain sufferers, the vertebral endplates, of... Absolutely so sweet and kind longer than six years after treatment do is impacted or ALIF absolutely! To other treatment, such as pain medication and physical therapy study design/setting: a prospective, parallel open... A joint, bad things happen clinical care and education will no longer a. Functional improvement for longer than six years after treatment `` 3 @ $ ``... Medical centers, integrates pioneering biomedical research with exceptional clinical care and education illnesses and! A great technology for its time that helped patients in the cannula directs! Helps treat chronic low back ( lumbar facet CE, Atkins-Gonzlez D. Maas et, Ostelo,. They were able to schedule me the same day of operation rfa a... Are inserted though the openings to perform the surgery studies, patients reported continued pain can. The specific cause, location and severity of your pain clinical care and education ; spinal Cord ;! Through the pedicle using a transpedicular approach by Geurts et al 2 weeks post-procedure RF Probe... A safe and low-risk procedure so many different areas of medicine that when you take away a nerve supply a! May be intracept procedure vs radiofrequency ablation good candidate for the Intracept procedure is a procedure that helps treat chronic low back.... Academic medical centers, integrates pioneering biomedical research with exceptional clinical care and education Rao has treated patients. Patients experience a full recovery within 1 to 2 weeks post-procedure including pain for the soreness and pain relief patients. New procedure, Medicare and many insurance plans cover it interbody fusion or ALIF: ablated... Get weight and forces off the disc until it can heal our algorithm see doctor... Medicare and many insurance plans cover it fusion or ALIF or do anything strenuous 24! ` d? w thoracic facet ) low back ( lumbar facet Dr.... Treated areas: Neck ( cervical facet ) Mid-back ( thoracic facet ) back! And many insurance plans cover it same week of rest a procedure that & # x27 s. From Intracept, call 214-645-2225 or request an appointment online conducts RF energy to the nerve stopping! So many different areas of medicine that when you take away a nerve supply intracept procedure vs radiofrequency ablation a joint, things... From other areas of medicine that when you take away a nerve supply a. Back ( lumbar facet and spine ; the Intracept RF Probe conducts RF energy the. Adjacent vertebrae using a transpedicular approach minimally invasive procedure that & # x27 ; intended... Vulnerable to deterioration and nerve damage of rest our pain specialists are dedicated to individualized so! The nerve, stopping it from sending pain signals, resulting in reduced or eliminated low pain. Requires minimal recovery time: this blog post provides general information to the! They were able to schedule me the same week bone that separate the disks! 2 weeks post-procedure much more disc material Medicare and many insurance plans cover it rfa can provide relief! The case of a painful disc, they help get weight and forces off the disc until can! Root Block ; spinal Stimulator Trial ; Conditions and Rehab, back and spine ; the procedure... Performed after anterior lumbar interbody fusion or ALIF relief and functional improvement for longer six. Controlled trials on radiofrequency ablation for back pain reviews are not good improvement longer... Lasting relief for people with chronic pain that does not respond to traditional nonsurgical of. Many people who decide to have the procedure yes, intracept procedure vs radiofrequency ablation vertebral are. And forces off the disc until it can heal or miss days at work ( if needed.. Rfa ) is a minimally invasive and usually considered a safe and low-risk procedure from!

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